Vaccine approaches conferring cross-protection against influenza viruses
Identifieur interne : 000638 ( Main/Exploration ); précédent : 000637; suivant : 000639Vaccine approaches conferring cross-protection against influenza viruses
Auteurs : Sai V. Vemula [États-Unis] ; Ekramy E. Sayedahmed [États-Unis] ; Suryaprakash Sambhara [États-Unis] ; Suresh K. Mittal [États-Unis]Source :
- Expert review of vaccines [ 1476-0584 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Orthomyxoviridae, Vaccins antigrippaux.
- isolement et purification : Vaccins antigrippaux.
- Découverte de médicament, Grippe humaine, Humains, Protection croisée.
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Influenza Vaccines.
- chemical , isolation & purification : Influenza Vaccines.
- immunology : Orthomyxoviridae.
- methods : Drug Discovery.
- prevention & control : Influenza, Human.
- Cross Protection, Humans.
Abstract
Annual vaccination is one of the most efficient and cost-effective strategies to prevent and control influenza epidemics. Most of currently available influenza vaccines are strong inducer of antibody responses against viral surface proteins, hemagglutinin (HA) and neuraminidase (NA), but are poor inducers of cell-mediated immune responses against conserved internal proteins. Moreover, due to the high variability of viral surface proteins because of antigenic drift or antigenic shift, many of the currently licensed vaccines confer little or no protection against drift or shift variants.
Next generation influenza vaccines that can induce humoral immune responses to receptor-binding epitopes as well as broadly neutralizing conserved epitopes, and cell-mediated immune responses against highly conserved internal proteins would be effective against variant viruses as well as a novel pandemic influenza until circulating strain-specific vaccines become available. Here we discuss vaccine approaches that have potential to provide broad spectrum protection against influenza viruses.
Based on current progress in defining cross-protective influenza immunity, it seems that the development of a universal influenza vaccine is feasible. It would revolutionize the strategy for influenza pandemic preparedness, and significantly impact the shelf-life and protection efficacy of seasonal influenza vaccines.
Url:
DOI: 10.1080/14760584.2017.1379396
PubMed: 28925296
PubMed Central: 6005355
Affiliations:
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Le document en format XML
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Vemula</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Comparative Pathobiology, and Purdue Institute for Immunology, Inflammation and Infectious Diseases, Purdue University, West Lafayette, IN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Comparative Pathobiology, and Purdue Institute for Immunology, Inflammation and Infectious Diseases, Purdue University, West Lafayette, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Sayedahmed, Ekramy E" sort="Sayedahmed, Ekramy E" uniqKey="Sayedahmed E" first="Ekramy E" last="Sayedahmed">Ekramy E. Sayedahmed</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Comparative Pathobiology, and Purdue Institute for Immunology, Inflammation and Infectious Diseases, Purdue University, West Lafayette, IN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Comparative Pathobiology, and Purdue Institute for Immunology, Inflammation and Infectious Diseases, Purdue University, West Lafayette, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Sambhara, Suryaprakash" sort="Sambhara, Suryaprakash" uniqKey="Sambhara S" first="Suryaprakash" last="Sambhara">Suryaprakash Sambhara</name><affiliation wicri:level="2"><nlm:aff id="A2">Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Mittal, Suresh K" sort="Mittal, Suresh K" uniqKey="Mittal S" first="Suresh K." last="Mittal">Suresh K. Mittal</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Comparative Pathobiology, and Purdue Institute for Immunology, Inflammation and Infectious Diseases, Purdue University, West Lafayette, IN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Comparative Pathobiology, and Purdue Institute for Immunology, Inflammation and Infectious Diseases, Purdue University, West Lafayette, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author></analytic><series><title level="j">Expert review of vaccines</title><idno type="ISSN">1476-0584</idno><idno type="eISSN">1744-8395</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cross Protection</term><term>Drug Discovery (methods)</term><term>Humans</term><term>Influenza Vaccines (immunology)</term><term>Influenza Vaccines (isolation & purification)</term><term>Influenza, Human (prevention & control)</term><term>Orthomyxoviridae (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Découverte de médicament ()</term><term>Grippe humaine ()</term><term>Humains</term><term>Orthomyxoviridae (immunologie)</term><term>Protection croisée</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins antigrippaux (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Orthomyxoviridae</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Discovery</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cross Protection</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Découverte de médicament</term><term>Grippe humaine</term><term>Humains</term><term>Protection croisée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Introduction</title><p id="P3">Annual vaccination is one of the most efficient and cost-effective strategies to prevent and control influenza epidemics. Most of currently available influenza vaccines are strong inducer of antibody responses against viral surface proteins, hemagglutinin (HA) and neuraminidase (NA), but are poor inducers of cell-mediated immune responses against conserved internal proteins. Moreover, due to the high variability of viral surface proteins because of antigenic drift or antigenic shift, many of the currently licensed vaccines confer little or no protection against drift or shift variants.</p></sec><sec id="S2"><title>Areas covered</title><p id="P4">Next generation influenza vaccines that can induce humoral immune responses to receptor-binding epitopes as well as broadly neutralizing conserved epitopes, and cell-mediated immune responses against highly conserved internal proteins would be effective against variant viruses as well as a novel pandemic influenza until circulating strain-specific vaccines become available. Here we discuss vaccine approaches that have potential to provide broad spectrum protection against influenza viruses.</p></sec><sec id="S3"><title>Expert opinion</title><p id="P5">Based on current progress in defining cross-protective influenza immunity, it seems that the development of a universal influenza vaccine is feasible. It would revolutionize the strategy for influenza pandemic preparedness, and significantly impact the shelf-life and protection efficacy of seasonal influenza vaccines.</p></sec></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Indiana</li></region></list><tree><country name="États-Unis"><region name="Indiana"><name sortKey="Vemula, Sai V" sort="Vemula, Sai V" uniqKey="Vemula S" first="Sai V." last="Vemula">Sai V. Vemula</name></region><name sortKey="Mittal, Suresh K" sort="Mittal, Suresh K" uniqKey="Mittal S" first="Suresh K." last="Mittal">Suresh K. Mittal</name><name sortKey="Sambhara, Suryaprakash" sort="Sambhara, Suryaprakash" uniqKey="Sambhara S" first="Suryaprakash" last="Sambhara">Suryaprakash Sambhara</name><name sortKey="Sayedahmed, Ekramy E" sort="Sayedahmed, Ekramy E" uniqKey="Sayedahmed E" first="Ekramy E" last="Sayedahmed">Ekramy E. Sayedahmed</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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